Substituted 1, 3, 4-thiadiazoles with anticonvulsant activity. 3. Guanidines

CB Chapleo, PL Myers, ACB Smith…

文献索引：Chapleo, Christopher B.; Myers, Peter L.; Smith, Alan C. B.; Tulloch, Ian F.; Walter, Donald S. Journal of Medicinal Chemistry, 1987 ,  vol. 30,  # 5  p. 951 - 954

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被引用次数: 33

摘要

The synthesis and anticonvulsant activity of a number of 2-aryl-5-guanidino-l, 3, 4 thiadiazoles are described. The unsubstituted guanidine 2a was found to possess potent anticonvulsant properties; considerable reduction or loss of activity however was observed with the majority of the substituted guanidines. Incorporation of the guanidine group into an imidazoline ring also resulted in a loss of activity. Secondary pharmacological evaluation ...