Synthesis and in vitro anti-HSV-1 activity of a novel Hsp90 inhibitor BJ-B11

…, CW Qian, Z Ren, SY Wang, YF Wang, GW Xing

文献索引：Ju, Huai-Qiang; Xiang, Yang-Fei; Xin, Bao-Juan; Pei, Ying; Lu, Jia-Xin; Wang, Qiao-Li; Xia, Min; Qian, Chui-Wen; Ren, Zhe; Wang, Sha-Yan; Wang, Yi-Fei; Xing, Guo-Wen Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1675 - 1677

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被引用次数: 16

摘要

In this study, a novel Hsp90 inhibitor BJ-B11, was synthesized and evaluated for in vitro antiviral activity against several viruses. Possible anti-HSV-1 mechanisms were also investigated. BJ-B11 displayed no antiviral activity against coxsackievirus B3 (CVB3), human respiratory syncytial virus (RSV) and influenza virus (H1N1), but exhibited potent anti- HSV-1 and HSV-2 activity with EC50 values of 0.42±0.18 μM and 0.60±0.21 μM, ...