Studies on antidiabetic agents. 11. Novel thiazolidinedione derivatives as potent hypoglycemic and hypolipidemic agents

T Sohda, K Mizuno, Y Momose, H Ikeda…

文献索引：Sohda; Mizuno; Momose; Ikeda; Fujita; Meguro Journal of Medicinal Chemistry, 1992 ,  vol. 35,  # 14  p. 2617 - 2626

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被引用次数: 121

摘要

Insulin resistance is a characteristic feature of noninsulin-dependent diabetes mellitus (NIDDM), in particular when it is associated with obesity. This insulin-resistant state at the peripheral tissue level causes impaired glucose utilization leading to hyperglycemia3 Therefore, amelioration of insulin resistance with a drug would provide a novel and useful means of treating NIDDM. With regard to this concept3s4 few drugs have, however, been