… structure determination and antiinflammatory activity of the regioisomers: 5??phenyl??6??(4??pyridyl)??2, 3??dihydroimidazo [2, 1??b] thiazole and 6??phenyl??5??(4??pyridyl)??2, …
Abstract A regiospecific synthesis of 6-phenyl-5-(4-pyridyl)-2, 3-dihydroimidazo [2, 1-b] thiazole (2) was accomplished by treatment of 6-phenyl-2, 3-dihydroimidazo [2, 1-b] thiazole (10) with the reactive complex of pyridine and ethyl chloroformate followed by oxidation with chromium (VI) oxide. Reaction of 4-phenyl-5-(4-pyridyl) imidazole-2-thione (12) with 1, 2- dibromoethane in the presence of base also gave 2 together with its regioisomer 3. The ...
