… of nucleophilic centres and the activation of alternative locations to electrophilic attack.: Part III11Part II: AR Katritzky and K. Akutagawa, Tetrahedron, submitted.. A new …
AR Katritzky, WQ Fan, K Akutagawa
文献索引：Katritzky, Alan R.; Fan, Wei-Qiang; Akutagawa, Kunihiko Tetrahedron, 1986 , vol. 42, # 14 p. 4027 - 4034
N-Methyl-and M-ethyl-aniline are regiospecifically converted into a range of ortho- substituted derivatives, using carbon dioxide both for M-protection and as an intermediate carbanion stabilizing group, and t-butyllithium to lithiate the ortho-carbon atom. The resulting lithium N-(ortho-substituted-phenyl)-N-methyl-and-N-ethyl-carbamates undergo smooth acid- catalysed decarboxylation under mild conditions. No alpha-substituted products were ...
