Abstract Difficult-to-access chiral primary amines were formed in good to high yield and ee using a rare example of a one-pot synthesis from prochiral ketones (sequential reductive amination-hydrogenloysis). As a highlight we also demonstrate a one-pot reductive amination-hydrogenolysis-reductive amination (five reactions) of ortho- methoxyacetophenone resulting in the chiral diamine 1-(2-methoxyphenyl) ethyl-(2- ...
