Syntheses of the tricyclic cores of clozapine, dibenzo [b, f][1, 4] thiazepin??11 (10H)??one, and dibenzo [b, f][1, 4] oxazepin??11 (10H)??one in C??14 labeled form by [14C] …

…, PN Dorff, J Richard Heys

文献索引：Elmore, Charles S.; Dorff, Peter N.; Richard Heys Journal of Labelled Compounds and Radiopharmaceuticals, 2010 ,  vol. 53,  # 13  p. 787 - 792

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被引用次数: 9

摘要

Abstract Clozapine has been demonstrated to bind covalently to proteins as a result of metabolic activation that has been proposed to be a precursor to the serious side effects including death that occur in a small percentage of the population. The covalent modification of proteins by clozapine has been studied by several groups and is well documented; therefore, the department of drug metabolism desired to use [14 C] clozapine as a positive ...