Organic letters

Synthesis of 3 H-Pyrazolo [3, 4-c] isoquinolines and Thieno [3, 2-c] isoquinolines via Cascade Imination/Intramolecular Decarboxylative Coupling

G Pandey, S Bhowmik, S Batra

文献索引：Pandey, Garima; Bhowmik, Subhendu; Batra, Sanjay Organic Letters, 2013 , vol. 15, # 19 p. 5044 - 5047

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被引用次数: 13

摘要

A general approach for the synthesis of 3 H-pyrazolo [3, 4-c] isoquinolines and thieno [3, 2-c] isoquinolines is described involving the implementation of a cascade imination/ intramolecular decarboxylative coupling between potassium 2-amino (hetero) benzoates and 2-haloarylaldehydes. The reactions of pyrazole-based substrates require a Pd–Cu bimetallic system for superior yields whereas the thienyl-based substrates afford the ...