Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS

…, S Su, H Treutlein, S San Wan, J Zeng, AF Wilks

文献索引：Burns, Christopher J.; Harte, Michael F.; Bu, Xianyong; Fantino, Emmanuelle; Giarrusso, Marilena; Joffe, Max; Kurek, Margarita; Legge, Fiona S.; Razzino, Pasquale; Su, Stephen; Treutlein, Herbert; Wan, Soo San; Zeng, Jun; Wilks, Andrew F. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 4 p. 1206 - 1209

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被引用次数: 15

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of 2-(α-methylbenzylamino) pyrazines have shown to be potent inhibitors of the FMS tyrosine receptor kinase. Details of SAR studies, modeling and synthesis of compounds within this series are reported. ... A novel series of 2-(α-methylbenzylamino) pyrazines have been ...