As part of an ongoing project it was necessary to access a series of novel 4-arylphenols containing sterically demanding functionality at the 3-position; in particular phenols with isopropyl, tert-butyl, and phenyl groups were of interest for our work. A viable approach to these compounds via palladium-catalysed coupling of the 3-alkyl- and 3-aryl-4-halophenols 1 (Figure [1] ) was proposed. However, literature searches revealed a paucity of information regarding the ...
