Synthesis and antimicrobial evaluation of farnesyl diphosphate mimetics

IJS Fairlamb, JM Dickinson, R O'Connor, LH Cohen…

文献索引：Fairlamb, Ian J.S.; Dickinson, Julia M.; O'Connor, Rachael; Cohen, Louis H.; Van Thiel, Christa F. Bioorganic Chemistry, 2003 , vol. 31, # 1 p. 80 - 97

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被引用次数: 11

摘要

The synthesis and first antimicrobial evaluation of farnesyl diphosphate mimetics are described. Several analogues (10, 12, 13, and 20) are inhibitors of Candida albicans, Shizosaccharomyces pombe, and Saccharomyces cerevisiae. The activities of analogues 10, 12, and 13, which contain a ω-phenyl moiety and a diphosphate isostere, are not attributable to inhibition of sterol biosynthesis via squalene synthase. Two geranyl ...