N-arylsulfonyl hydrazones as inhibitors of IMP-1 metallo-β-lactamase

…, AJ Clarke, T Viswanatha, GI Dmitrienko

文献索引：Siemann, Stefan; Evanoff, Darryl P.; Marrone, Laura; Clarke, Anthony J.; Viswanatha, Thammaiah; Dmitrienko, Gary I. Antimicrobial Agents and Chemotherapy, 2002 , vol. 46, # 8 p. 2450 - 2457

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被引用次数: 90

摘要

ABSTRACT Members of a family of N-arylsulfonyl hydrazones have been identified as novel inhibitors of IMP-1, a metallo-β-lactamase of increasing prevalence. Structure-activity relationship studies have indicated a requirement for bulky aromatic substituents on each side of the sulfonyl hydrazone backbone for these compounds to serve as efficient inhibitors of IMP-1. Molecular modeling has provided insight into the structural basis for the anti- ...