An alternative method for the synthesis of γ-lactones by using cesium fluoride-celite/acetonitrile combination

…, S Hayat, Zia-Ullah, Atta-ur-Rahman…

文献索引：Khan, Khalid Mohammed; Hayat, Safdar; Zia-Ullah; Atta-ur-Rahman; Iqbal-Choudhary; Maharvi, Ghulam Murtaza; Bayert, Ernst Synthetic Communications, 2003 , vol. 33, # 19 p. 3435 - 3453

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被引用次数: 16

摘要

Abstract A variety of 2-(1-bromoalkyl) benzoic acids 4 undergo intramolecular nucleophilic substitution reaction when treated with a CsF-Celite as solid base in acetonitrile under reflux condition to give the corresponding cyclized phthalides in moderate to very good yield. These 2-(1-bromoalkyl) benzoic acids 4 are formed by the α-bromination of 2-alkylbenzoic acids 3 using N-bromosuccinimide and a catalytic amount of α, α′-azoisobutyronitrile in ...