Rhodium-Catalyzed Stereoselective Intramolecular [5+ 2] Cycloaddition of 3-Acyloxy 1, 4-Enyne and Alkene
X Shu, CM Schienebeck, X Li, X Zhou, W Song…
文献索引：Shu, Xing-Zhong; Li, Xiaoxun; Shu, Dongxu; Huang, Suyu; Schienebeck, Casi M.; Zhou, Xin; Robichaux, Patrick J.; Tang, Weiping Journal of the American Chemical Society, 2012 , vol. 134, # 11 p. 5211 - 5221
The first rhodium-catalyzed intramolecular [5+ 2] cycloaddition of 3-acyloxy 1, 4-enyne and alkene was developed. The cycloaddition is highly diastereoselective in most cases. Various cis-fused bicyclo [5.3. 0] decadienes were prepared stereoselectively. The chirality in the propargylic ester starting materials could be transferred to the bicyclic products with high efficiency. Electron-deficient phosphine ligand greatly facilitated the cycloaddition. Up to ...
