Racemization of secondary alcohols catalyzed by ruthenium: Application to chemoenzymatic dynamic resolution

…, N Vriamont, L Aribi-Zouioueche, O Riant

文献索引：Merabet-Khelassi, Mounia; Vriamont, Nicolas; Aribi-Zouioueche, Louisa; Riant, Olivier Tetrahedron Asymmetry, 2011 , vol. 22, # 18-19 p. 1790 - 1796

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被引用次数: 17

摘要

In this paper, we have shown that the [RuCl2 (p-cymene)] 2 complex associated with simple hemisalen ligands is able to racemize (S)-1-phenylethanol. The influence on the racemization process of the ligand's structure as well as the nature of a co-catalyst have been evaluated and optimized. This [RuCl2 (p-cymene)] 2/Ligand/TEMPO racemization system was then associated with the Candida Antarctica B lipase in order to carry out ...