New Disulfide Route to 3-(1-Piperazinyl)-1, 2-benzisothiazole. Nucleus for Atypical Antipsychotic Drugs

SW Walinsky, DE Fox, JF Lambert…

文献索引：Nakamura, Toshio; Nagata, Hideo; Muto, Masayuki; Saji, Ikutaro Synthesis, 1997 , # 8 p. 871 - 873

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被引用次数: 10

摘要

... Table 1. Process optimization and synthesis of 3-amino-1,2-benzisothiazoles. ... 110.24, 57.34, 47.06; HR MS found 220.0878; C 11 H 13 N 3 S requires (FAB P + 1) 220.0908. ... 8 (1.25 g, 4.66 mmol), anhydrous piperazine (4.01 g, 46.6 mmol), and DMSO (0.80 g, 10.3 mmol) in 15 ...