A potent and orally active HIV-1 integrase inhibitor

…, MM Zrada, AR Cortes, A Wallace, Y Leonard…

文献索引：Egbertson, Melissa S.; Moritz, H. Marie; Melamed, Jeffrey Y.; Han, Wei; Perlow, Debra S.; Kuo, Michelle S.; Embrey, Mark; Vacca, Joseph P.; Zrada, Matthew M.; Cortes, Amanda R.; Wallace, Audrey; Leonard, Yvonne; Hazuda, Daria J.; Miller, Michael D.; Felock, Peter J.; Stillmock, Kara A.; Witmer, Marc V.; Schleif, William; Gabryelski, Lori J.; Moyer, Gregory; Ellis, Joan D.; Jin, Lixia; Xu, Wei; Braun, Matthew P.; Kassahun, Kellem; Tsou, Nancy N.; Young, Steven D. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1392 - 1398

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被引用次数: 28

摘要

Replication of the human immunodeficiency virus (HIV) is dependent upon the enzyme HIV Integrase (IN), one of three essential enzymes encoded in the viral genome. HIV IN catalyzes the insertion of the viral genome into the host genome. HIV IN subunits assemble onto double stranded viral DNA and process the 3′ ends to prepare the strand for integration. The pre-integration complex then enters the nucleus where it catalyzes the DNA insertion (strand transfer) step. ...