Chemical predisposition in synthesis: application to the preparation of the pyrrolidine natural products, plakoridines A and B
…, M Helliwell, NM Kershaw, A Sardarian, RC Whitehead
文献索引：Etchells, Laura L.; Helliwell, Madeleine; Kershaw, Neil M.; Sardarian, Ali; Whitehead, Roger C. Tetrahedron, 2006 , vol. 62, # 47 p. 10914 - 10927
The pyrrolidine natural products, plakoridines A and B, as well as an array of unnatural analogues, have been prepared using a five-step synthetic sequence modelled on a biogenetic theory. The key transformation involves a 'Mannich/Michael/internal- redox'cascade, which proceeds in yields of 31–63%.
