Partially modified retro-inverso enkephalin analogues containing Gly 3 Ψ (NH-CO) Phe 4 modification, Configurational lability

…, E Ackerman, D Levian-Teitelbaum…

文献索引：Chorev, Michael; Gilon, Noemy; Roubini, Eli; Ackerman, Elizabeth; Levian-Teitelbaum, Dina; Rosin, Marta Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 11A p. 2519 - 2536

全文：HTML全文

被引用次数: 6

摘要

Abstract Two partially modified retro-inverso analogues of Leu-enkephalin in which the peptide bond between Gly 3-Phe 4 was reversed resulted from the incorporation of the Gly 3 ψ (NH-CO) Phe 4 unit. The presence of racemic 2-benzylmalonyl residue led to diastereomeric mixtures of analogues; H-Tyr-D-Ala-gGly-(RS)-mPhe-Leu-NH 2 (I) and H-Tyr- Gly-gGly-(RS)-mPhe-Leu-NH 2 (II). Analogue I was more potent than analogue II in the ...