Synthesis and analgesic activity of some 5-(4-hydroxyphenyl)-2-azabicyclo [3.2. 1] octanes

…, VB Anderson, JC Wilker, TC Spaulding…

文献索引：Ong; Anderson; Wilker; Spaulding; Meyerson Journal of Medicinal Chemistry, 1980 , vol. 23, # 7 p. 726 - 729

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被引用次数: 6

摘要

A representative series of 5-(4-hydroxyphenyl)-2-azabicyclo [3.2. l] octanes was synthesized and evaluated in vitro, as well as in vivo, as potential analgetic agents. In general, moderate to good activity (19 twice as active as morphine) was observed in the phenylquinone writhing assay (PQW), while only marginal activity waa detected by the tail-flick method. Compounds 19 and 18, being the most active in the PQW model, also demonstrated weak ...