An efficient synthesis of 1-phenyl-1-piperidino-trans-4-methylcyclohexane: Unanticipated total stereoselectivity in the catalytic hydrogenation of an olefin
FJ Vinick, J Nowakowska, S Jung
文献索引：Vinick, F.J.; Nowakowska, J.; Jung, S. Tetrahedron Letters, 1987 , vol. 28, # 7 p. 741 - 744
Abstract A superior synthesis of the title compound, 1-phenyl-1-piperidino-trans-4- methylcyclohexane, is reported. The key step, the catalytic hydrogenation of 1-phenyl-1- piperidino-4-methylenecyclohexane hydrochloride, proceeds with unusual stereospecificity via addition of hydrogen trans to the axial phenyl substituent.
