Asymmetric synthesis of enantiomeric cyclophosphamides

…, H Ueda, K Nakagawa, N Bodor

文献索引：Sato, Tadao; Ueda, Hiraki; Nakagawa, Kazuyuki; Bodor, Nicholas Journal of Organic Chemistry, 1983 , vol. 48, # 1 p. 98 - 101

全文：HTML全文

被引用次数: 22

摘要

An efficient asymmetric synthesis of the enantiomers of cyclophosphamide was developed on the basis of three important steps:(1) a highly stereospecific synthesis of the 2-chloro-2- oxo-1, 3, 2-oxazaphosphorinane ring from an optically active amino alcohol and phosphoryl chloride (diastereomer ratio obtained is 101 to 12: l);(2) the use of the diethanolamine derivative tu an intermediate for introduction of the mustard group;(3) a novel, simple, and ...