Highly Efficient and Enantioselective Iridium??Catalyzed Asymmetric Hydrogenation of N??Arylimines

W Li, G Hou, M Chang, X Zhang

文献索引：Li, Wei; Hou, Guohua; Chang, Mingxin; Zhang, Xumu Advanced Synthesis and Catalysis, 2009 , vol. 351, # 18 p. 3123 - 3127

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被引用次数: 28

摘要

Abstract A catalytic method employing the cationic iridium-(S c, R p)-DuanPhos [(1R, 1′ R, 2S, 2′ S)-2, 2′-di-tert-butyl-2, 2′, 3, 3′-tetrahydro-1H, 1′ H-1, 1′-biisophosphindole] complex and BARF {tetrakis [3, 5-bis (trifluoromethyl) phenyl] borate} counterion effectively catalyzes the enantioselective hydrogenation of acyclic N-arylimines with high turnover numbers (up to 10,000 TON) and excellent enantioselectivities (up to 98% ee), achieving ...