Hypolipidemic alkoxybenzoic acids

VG Devries, DB Moran, GR Allen…

文献索引：DeVries; Moran; Allen; Riggi Journal of Medicinal Chemistry, 1976 , vol. 19, # 7 p. 946 - 957

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被引用次数: 22

摘要

iodo-2-methylbenzoate (7.0 g, 25 mmol), active Cu16 (10 g, dried under vacuum at 100- 110'for 5 h), and CF3I (17 g, 87 mmol) in dry DMF (14 ml) were put into a stainless tube which was chilled at-40 to-50'. The sealed tube was heated at 130-140'for 72 h. After cooling, the reaction mixture was shaken with CHC13. The washed, dried CHC13 extract was concentrated and the residue was separated on silica gel chromatography using C $ ...