Thermal characterization of the solid state and raw material fluconazole by thermal analysis and pyrolysis coupled to GC/MS

EA Moura, LP Correia, MF Pinto, JVV Procópio…

文献索引：Moura, Elisana Afonso; Correia, Lidiane Pinto; Pinto, Marcia Ferraz; Procopio, Jose Valdilanio Virgulino; De Souza, Fabio Santos; MacEdo, Rui Oliveira Journal of Thermal Analysis and Calorimetry, 2010 , vol. 100, # 1 p. 289 - 293

全文：HTML全文

被引用次数: 29

摘要

Abstract This article had studied the thermal characterization of the raw material and different fluconazole crystals, obtained through recrystallization with different solvents using thermoanalytical techniques (TG, DTA, DSC-50, DSC Photovisual, DSC-60) and Pyr-GC/MS. The results confirmed that the fluconazole volatilizes without decomposition until 250° C. Pyr- GC/MS showed hexachlorobenzene like impurities in fluconazole raw material.