Targeting delavirdine/atevirdine resistant HIV-1: identification of (alkylamino) piperidine-containing bis (heteroaryl) piperazines as broad spectrum HIV-1 reverse …
…, RA Olmsted, TJ Poel, RA Morge, C Biles…
文献索引：Romero, Donna L.; Olmsted, Robert A.; Poel, Toni Jo; Morge, Raymond A.; Biles, Carolyn; Keiser, Barbara J.; Kopta, Laurice A.; Friis, Jan M.; Hosley, John D.; Stefanski, Kevin J.; Wishka, Donn G.; Evans, David B.; Morris, Joel; Stehle, Randy G.; Sharma, Satish K.; Yagi, Yoshihiko; Voorman, Richard L.; Adams, Wade J.; Tarpley, W. Gary; Thomas, Richard C. Journal of Medicinal Chemistry, 1996 , vol. 39, # 19 p. 3769 - 3789
A novel class of bis (heteroaryl) piperazine (BHAP) analogs which possesses the ability to inhibit NNRTI (non-nucleoside reverse transcriptase inhibitor) resistant recombinant HIV-1 reverse transcriptase (RT) and NNRTI resistant variants of HIV-1 has been identified via targeted screening. Further investigation of the structure-activity relationships of close congeners of these novel (alkylamino) piperidine BHAPs (AAP-BHAPs) led to the ...
