Thiazolidin-4-one formation. Mechanistic and synthetic aspects of the reaction of imines and mercaptoacetic acid under microwave and conventional heating
Microwave irradiation of a mixture of benzylidene-anilines and mercaptoacetic acid in benzene gives 1, 3-thiazolidin-4-ones in very high yield (65–90%), whereas the same reaction performed through using the conventional method, at reflux temperature, requires a much longer time and gives a much lower yield (25–69%). This difference seems to be due to some intermediates and by-products formed during the conventional reaction. On the ...
