New, Regioselective, One??Pot Synthesis of (all??E)??Retinoic Acid and Analogues from Enaminodiester Synthons

…, A Valla, RL Guillou, R Labia, P Potier

文献索引：Cartier, Dominique; Valla, Alain; Le Guillou, Regis; Labia, Roger; Potier, Pierre European Journal of Organic Chemistry, 2003 , # 12 p. 2250 - 2253

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被引用次数: 3

摘要

Abstract A one-pot synthesis of (all-E)-retinoic acid and related compounds from new enamino diester synthons is described. The enamino diesters was produced nearly quantitatively from methyl propylidene-and isopropylidenemalonate and DMF− DMA. This easy process allowed retinoic acid to be produced in 1 d and appeared advantageous to current industrial syntheses.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, ...