“Clicked” Bivalent Ligands Containing Curcumin and Cholesterol As Multifunctional Aβ Oligomerization Inhibitors: Design, Synthesis, and Biological Characterization

…, R Gandhi, TL Guo, PM Gerk, DH Brunzell…

文献索引：Lenhart, James A.; Ling, Xiao; Gandhi, Ronak; Guo, Tai L.; Gerk, Phillip M.; Brunzell, Darlene H.; Zhang, Shijun Journal of Medicinal Chemistry, 2010 , vol. 53, # 16 p. 6198 - 6209

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被引用次数: 48

摘要

In our effort to develop multifunctional compounds that cotarget beta-amyloid oligomers (AβOs), cell membrane/lipid rafts (CM/LR), and oxidative stress, a series of bivalent multifunctional Aβ oligomerization inhibitors (BMAOIs) containing cholesterol and curcumin were designed, synthesized, and biologically characterized as potential treatments for Alzheimer's disease (AD). The in vitro assay results established that the length of spacer ...