Synthesis of long-chain fatty acid derivatives as a novel anti-Alzheimer's agent

HY Zhang, Y Yamakawa, Y Matsuya, N Toyooka…

文献索引：Zhang, Hong-Yan; Yamakawa, Yu-Ichiro; Matsuya, Yuji; Toyooka, Naoki; Tohda, Chihiro; Awale, Suresh; Li, Feng; Kadota, Shigetoshi; Tezuka, Yasuhiro Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 2 p. 604 - 608

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被引用次数: 2

摘要

Abstract In order to develop new drugs for Alzheimer's disease, we prepared 17 fatty acid derivatives with different chain lengths and different numbers and positions of double bonds by using Wittig reaction and stereospecific hydrogenation of triple bonds as key reactions. Among them,(4Z, 15Z)-octadecadienoic acid (10) and (23Z, 34Z)-heptatriacontadienoic acid (16) showed the most potent neurite outgrowth activities on Aβ (25–35)-treated rat cortical ...