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Copper-catalyzed synthesis of 2-imidazolines and their N-hydroxyethyl derivatives under various conditions

J Zhang, X Wang, M Yang, K Wan, B Yin, Y Wang, J Li…

文献索引:Zhang, Jin; Wang, Xiao; Yang, Meipan; Wan, Kerou; Yin, Bing; Wang, Yunxia; Li, Jianli; Shi, Zhen Tetrahedron Letters, 2011 , vol. 52, # 14 p. 1578 - 1582

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被引用次数: 11

摘要

A rapid and efficient method for the synthesis of 2-imidazolines and their N-hydroxyethyl derivatives from the reaction of aromatic nitriles with ethylenediamine (EDA) or N-(2- aminoethyl) ethanolamine (AEEA) using cupric indole-3-acetate (Cu (II)–(IAA) 2) as a reusable catalyst under reflux and microwave conditions is reported. And seven new N- hydroxyethyl-imidazolines were reported for the first time.