Tetrahedron

Synthetic studies on 3-arylquinazolin-4-ones: intramolecular nucleophilic aromatic substitution reaction of 2-carboxamido-3-arylquinazolin-4-ones and its application …

H Fuwa, T Kobayashi, T Tokitoh, Y Torii, H Natsugari

文献索引：Fuwa, Haruhiko; Kobayashi, Toshitake; Tokitoh, Takashi; Torii, Yukiko; Natsugari, Hideaki Tetrahedron, 2005 , vol. 61, # 17 p. 4297 - 4312

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被引用次数: 16

摘要

The general synthesis and a novel intramolecular nucleophilic aromatic substitution (SNAr) reaction of 2-carboxamido-3-arylquinazolin-4-ones, a potentially useful scaffold in the field of medicinal chemistry, are described. The synthetic utility of the SNAr reaction as a tool for the synthesis of secondary aryl amines, including diaryl amines, is also demonstrated.