Duloxetine (Cymbalta™), a dual inhibitor of serotonin and norepinephrine reuptake

…, JH Krushinski, S Mitchell, DW Robertson…

文献索引：Bymaster; Beedle; Findlay; Gallagher; Krushinski; Mitchell; Robertson; Thompson; Wallace; Wong Bioorganic and medicinal chemistry letters, 2003 , vol. 13, # 24 p. 4477 - 4480

全文：HTML全文

被引用次数: 100

摘要

A series of naphthalenyloxy-arylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. One member of this series, duloxetine (Cymbalta™) has proven to be effective in clinical trials for the treatment of depression.