Synthesis and biological activity of strongly fluorescent tricyclic analogues of acyclovir and ganciclovir

T Goslinski, B Golankiewicz, E De Clercq…

文献索引：Goslinski, Tomasz; Golankiewicz, Bozenna; De Clercq, Erik; Balzarini, Jan Journal of Medicinal Chemistry, 2002 , vol. 45, # 23 p. 5052 - 5057

全文：HTML全文

被引用次数: 32

摘要

In search of strongly fluorescent tricyclic analogues of acyclovir (ACV, 1) and ganciclovir (GCV, 2), derivatives of the 3, 9-dihydro-9-oxo-5 H-imidazo [1, 2-a] purine system, several 6- [4-(acyloxy) phenyl], 6-[4-(acylamino) phenyl], and 6-[4-(phenoxycarbonyloxy) phenyl]- substituted TACV and TGCV analogues were synthesized and evaluated for their activity against herpes simplex virus types 1 and 2 in cell culture. All TACV and TGCV analogues ...