Bioorganic & medicinal chemistry letters

Synthesis and topoisomerase II inhibitory and cytotoxic activity of oxiranylmethoxy-and thiiranylmethoxy-chalcone derivatives

Y Na, JM Nam

文献索引：Na, Younghwa; Nam, Jung-Min Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 211 - 214

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被引用次数: 17

摘要

In order to find potential anticancer drug candidate targeting topoisomerases enzyme, we have designed and synthesized oxiranylmethoxy-and thiiranylmethoxy-retrochalcone derivatives and evaluated their pharmacological activity including topoisomerases inhibitory and cytotoxic activity. Of the compounds prepared compound 25 showed comparable or better cytotoxic activity against cancer cell lines tested. Compound 25 inhibited MCF7 ( ...