Neurotropic and psychotropic agents. LX. 2-Acetyl-6H, 11H-dibenzo [b, e] thiepin and some related compounds

…, E Princová, J Grimová, M Protiva

文献索引：Rajsner; Princova; Grimova; Protiva Collection of Czechoslovak Chemical Communications, 1973 , vol. 38, # 5 p. 1602 - 1608

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摘要

Friedel-Crafts reaction of 6H, llH-dibenzo [b, e] thiepin (I) with acetyl chloride gives rise to the monoacetyl derivative II. Analogously, the 2-propionyl deriv~ tive III is formed. Willgerodt's reaction of these ketones was studied and thioamides V and VI and acids VII and VIII were obtained. Beckmann's rearrangement of oxime IX gave rise to the 2-acetamido derivative X. Oxidation of ketone II and acid VII yielded the sulfoxides XIII and XIV and further the ...