6, 6-Disubstituted hex-5-enoic acid derivatives as combined thromboxane A2 receptor antagonists and synthetase inhibitors

…, W Eisert, TH Mueller, H Weisenberger

文献索引：Soyka; Heckel; Nickl; Eisert; Muller; Weisenberger Journal of Medicinal Chemistry, 1994 , vol. 37, # 1 p. 26 - 39

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被引用次数: 38

摘要

A series of w-disubstituted alkenoic acid derivatives were designed and synthesized as antithrombotic inhibitors of thromboxane Az synthetase and thromboxane Az receptor antagonists. Hexenoic acid derivatives with a 3-pyridyl group and a 44 2- benzenesulfonamidoethy1) phenyl substituent were found to be optimal with regard to the dual mode of action. The most potent compound,(E)-6-(4-(2-(((Cchlorophen yl) sulfonyl) ...