Radioiodinated N-(2-diethylaminoethyl) benzamide derivatives with high melanoma uptake: structure-affinity relationships, metabolic fate, and intracellular localization

…, K Gorgas, WD Lehmann, U Haberkorn

文献索引：Eisenhut; Hull; Mohammed; Mier; Lay; Just; Gorgas; Lehmann; Haberkorn Journal of Medicinal Chemistry, 2000 , vol. 43, # 21 p. 3913 - 3922

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被引用次数: 67

摘要

Several radioiodinated N-(dialkylaminoalkyl) benzamides have been used for planar scintigraphy and single-photon emission computed tomography (SPECT) of melanoma metastases. In a quest for improved melanoma uptake and tissue selectivity, structure- activity studies for N-(2-diethylaminoethyl) benzamides with variation of phenyl substituents were performed using C57Bl/6 mice bearing B16 melanoma. Compounds 2 (4-amino-5- ...