4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists

…, T Ulven, PB Little, PK Nørregaard, T Högberg

文献索引：Receveur, Jean-Marie; Bjurling, Emelie; Ulven, Trond; Little, Paul Brian; Norregaard, Pia K.; Hoegberg, Thomas Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 20 p. 5075 - 5080

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被引用次数: 46

摘要

Synthesis, in vitro biological evaluation and structure–activity relationships of 4-acylamino- and 4-ureidobenzamides as novel hMCH1R-antagonists are disclosed. The nature of the amine side chains could be varied considerably in contrast to the central benzamide scaffold and aromatic substituents.