Structure− activity relationship studies of chalcone leading to 3-hydroxy-4, 3′, 4′, 5′-tetramethoxychalcone and its analogues as potent nuclear factor κB inhibitors …
B Srinivasan, TE Johnson, R Lad…
文献索引：Srinivasan, Balasubramanian; Johnson, Thomas E.; Lad, Rahul; Xing, Chengguo Journal of Medicinal Chemistry, 2009 , vol. 52, # 22 p. 7228 - 7235
Chalcone is a privileged structure, demonstrating promising anti-inflammatory and anticancer activities. One potential mechanism is to suppress nuclear factor kappa B (NF-κB) activation. The structures of chalcone-based NF-κB inhibitors vary significantly that there is minimum information about their structure− activity relationships (SAR). This study aims to establish SAR of chalcone-based compounds to NF-κB inhibition, to explore the feasibility ...
