During the last decade, efforts have been made to develop new organic oligomers backbones that adopt specific predefined architectures. These oligomers known as foldamers are designed to mimic natural biomolecule secondary structures such as β-sheets and helices. 1 Two different approaches have been used for the design of such compounds: (i) the “top-down approach”, which involves structural variation of parent chain molecules to create peptidomimetic 2 ...
