A labeled neutral endopeptidase inhibitor as a potential tool for tumor diagnosis and prognosis

…, J Barbet, BP Roques, A Gruaz??Guyon

文献索引：Raguin, Olivier; Fournie-Zaluski, Marie-Claude; Romieu, Anthony; Pelegrin, Andre; Chatelet, Francois; Pelaprat, Didier; Barbet, Jacques; Roques, Bernard P.; Gruaz-Guyon, Anne Angewandte Chemie - International Edition, 2005 , vol. 44, # 26 p. 4058 - 4061

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被引用次数: 8

摘要

Scheme 2. Synthesis of the NEP inhibitor AR58. a) Bis (trimethylsilyl)-acetamide, 708C; b) BOP, DIEA, NMP, solid-phase peptide synthesis then cleavage from the MBHA resin and final deprotection of the side chains of the amino acid residues (tert-butyl ether: Tyr, tert-butyl ester: Asp, N-tert-butoxycarbonyl: Lys) by trifluoroacetic acid to form R1 and the desired product. BOP= 1-benzotriazolyloxytris (dimethylamino)-phosphonium ...