Tetrahedron

Synthesis of 2-pyridones as tissue factor VIIa inhibitors

JJ Parlow, MS South

文献索引：Parlow, John J.; South, Michael S. Tetrahedron, 2003 , vol. 59, # 39 p. 7695 - 7701

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被引用次数: 30

摘要

2-Pyridones were prepared from 2, 6-dibromopyridine via a multi-step synthesis. A variety of chemical transformations, including regioselective nucleophilic addition and selective nitrogen alkylation, afforded the penultimate intermediate 9. A combination of two- dimensional NMR techniques to unequivocally assign the structure of 9 is described. Compound 9 was then used in a Suzuki coupling and further derivatized to afford the ...