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Aminobenzoic acid diuretics. 4. 4-Benzyl-5-sulfamylanthranilic acid derivatives and related 1, 2-benzisothiazole 1, 1-dioxides

PW Feit, OBT Nielsen…

文献索引:Feit,P.W. et al. Journal of Medicinal Chemistry, 1973 , vol. 16, p. 127 - 130

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被引用次数: 17

摘要

32 on the described 4-benzylanthranilic acids and benzisothiazoles equaled those of the previously reported'32 highceiling diuretics of the sulfamylanthranilic acid and 3- aminobenzoic acid series. In consideration of the absent free sulfonamide function, the high potency of the listed carboxybenzisothiazoles is rather interesting. However, a consideration of the following points led to an investigation into whether the diuretic activity should be ...