Molecules

Total synthesis, cytotoxic effects of damnacanthal, nordamnacanthal and related anthraquinone analogues

…, SK Yeap, WY Ho, KM Lo, A Hasan, NB Alitheen

文献索引：Akhtar, Muhammad Nadeem; Zareen, Seema; Yeap, Swee Keong; Ho, Wan Yong; Lo, Kong Mun; Hasan, Aurangzeb; Alitheen, Noorjahan Banu Molecules, 2013 , vol. 18, # 8 p. 10042 - 10055

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被引用次数: 8

摘要

Abstract: Naturally occurring anthraquinones, damnacanthal (1) and nordamnacanthal (2) were synthesized with modified reaction steps and investigated for their cytotoxicity against the MCF-7 and K-562 cancer cell lines, respectively. Intermediate analogues 2-bromomethyl- 1, 3-dimethoxyanthraquinone (5, IC 50= 5.70±0.21 and 8.50±1.18 μg/mL), 2-hydroxymethyl- 1, 3-dimethoxyanthraquinone (6, IC 50= 12.10±0.14 and 14.00±2.13), 2-formyl-1, 3- ...