The Synthesis and evaluation of a novel class of (E)-3-(1-cyclohexyl-1H-pyrazol-3-yl)-2-methylacrylic acid Hepatitis C virus polymerase NS5B inhibitors

…, S Roberts, K Rigat, R Fridell, D Qiu, G Knobloh…

文献索引：Martin, Scott W.; Glunz, Peter; Beno, Brett R.; Bergstrom, Carl; Romine, Jeffrey L.; Scott Priestley; Newman, Makenzie; Gao, Min; Roberts, Susan; Rigat, Karen; Fridell, Robert; Qiu, Dike; Knobloh, Galina; Wang, Ying-Kai Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 2869 - 2872

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被引用次数: 8

摘要

Abstract Herein we report the identification and evaluation of a novel series of (E)-3-(1- cyclohexyl-1H-pyrazol-3-yl)-2-methylacrylic acid derivatives identified from a deannulation study performed on the reported benzimidazole NS5B inhibitor, 1. This resulted in the identification of (E)-3-(2-(4-((4′-cyano-4-(4-hydroxypiperidine-1-carbonyl) biphenyl-2-yl) methoxy) phenyl)-1-cyclohexyl-1H-imidazol-4-yl)-2-methylacrylic acid (11) as a potent ...