Tetrahedron letters

Organometallic nucleophilic ring-opening of endo peroxides

MK Schwaebe, RD Little

文献索引：Schwaebe, Michael K.; Little, R. Daniel Tetrahedron Letters, 1996 , vol. 37, # 37 p. 6635 - 6638

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被引用次数: 23

摘要

The reaction of symmetrical and unsymmetrical endo peroxides with organometallic reagents affords hydroxy ethers. Primary, secondary, vinyl and aryl groups can be transferred with alkyllithium and Grignard reagents providing the best yields, organozincates, moderate. This demonstrates a new reactivity pattern for endoperoxides and provides a novel method for the formation of a variety of useful building blocks.