The Journal of organic chemistry

Synthesis of 2-amino-4-pyrimidinones from resin-bound guanidines prepared using bis (allyloxycarbonyl)-protected triflylguanidine

CW Zapf, M Goodman

文献索引：Zapf, Christoph W.; Goodman, Murray Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 10092 - 10097

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被引用次数: 18

摘要

We have synthesized novel heterocyclic compounds from resin-bound guanidines. For this purpose, an amine immobilized on a solid support was acylated with protected amino acids. Following the deprotection, the liberated amines were guanidinylated utilizing a new member of the family of diurethane-protected triflyl guanidine reagents, N, N'-bis (allyloxycarbonyl)-N''-triflylguanidine. The deprotected guanidines were subsequently ...