Tetrahedron

Synthesis and characterization of derivatives and dimers of 4, 5-dicyanoimidazole

EC Coad, H Liu, PG Rasmussen

文献索引：Coad, Eric C.; Liu, Hui; Rasmussen, Paul G. Tetrahedron, 1999 , vol. 55, # 10 p. 2811 - 2826

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被引用次数: 10

摘要

Synthesis of 1-methyl-2-fluoro-4, 5-dicyanoimidazole was accomplished by halogen exchange between 1-methyl-2-bromo-4, 5-dicyanoimidazole and potassium fluoride with catalytic 18-crown-6 ether in diglyme. Halogen exchange between 1-methyl-2-bromo-4, 5- dicyanoimidazole and lithium chloride in N-methylpyrrolidinone at 150° C yielded 1-methyl- 2-chloro-4, 5-dicyanoimidazole, while additional heating to 210° C resulted in the ...