Cardioselective antiischemic ATP-sensitive potassium channel openers. 2. structure-activity studies on benzopyranylcyanoguanidines; modification of the benzopyran …

…, GJ Grover, FN Ferrara, SZ Ahmed…

文献索引：Atwal, Karnail S.; Grover, Gary J.; Ferrara, Francis N.; Ahmed, Syed Z.; Sleph, Paul G.; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 11 p. 1966 - 1973

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被引用次数: 59

摘要

The ATP-sensitive potassium channel (KATP) openers are of considerable interest as myocardial protecting agents. However, there exists a narrow window of safety for the use of firstgeneration compounds as antiischemic agents due to their powerful peripheral vasodilating effects, which can result in underperfusion of the area already at risk. We have recently disclosed the discovery of benzopyranylcyanoguanidine type KATP openers ( ...